TY - JOUR AU - Brady Beltran Garate AU - Domingo Morales Luna AU - Pilar Quiñones Ávila AU - Fernando Hurtado de Mendoza Acurio AU - Esther Cotrina Montenegro AU - Luis Riva Gonzáles PY - 2008/03/31 Y2 - 2024/03/29 TI - Age-related and Epstein Barr virus-associated B-cell lymphoproliferative disorder: a 9-case report and literature review JF - ACTA MEDICA PERUANA JA - Acta Med Peru VL - 25 IS - 1 SE - CASE REPORTS DO - UR - http://www.amp.cmp.org.pe/index.php/AMP/article/view/1348 AB - Introduction: Age-related B-cell lymphoproliferative disorder associated with Epstein-Barr virus (EBV) is a newly described condition in our country. EBV infection may lead to a non-controlled growth of normally inactive B-lymphocytes, so lymphoproliferative disorders with an aggressive course and poor survival occur.Clinical cases: Nine Peruvian patients diagnosed with age-related B-cell lymphoproliferative disorder associated EBV were included in this report. All patients were positive for EBER test using chromogenic in situ hybridization (CISH). Morphology in every case corresponded to large-cell lymphoma. CD20, BCL6, CD10, and MUM-1/IRF4 histochemical expression was assessed using a tissue microarray. All nive patients had a phenotype not germinal center-like. Most of our patients were elderly subjects with a poor performance status, type B symptoms, high values in the International Prognostic Index (IPI) and advanced disease. Their survival was quite short.Conclusion: We report for the first time a new condition called age-related B-cell lymphoproliferative disorder associated EBV, which has an aggressive course and a poor prognosis. ER -