Melanonychia due to hydroxyurea

Keywords: Hydroxyurea, Nail diseases, Drug-Related Side Effects and Adverse Reactions

Abstract

We present the case of an 85-year-old woman who was diagnosed with essential thrombocytosis; and, who, after six months receiving therapy with hydroxyurea, she noticed her fingernails turned dark. The exact mechanism for this occurrence is still unknown. We should pay attention to this unusual complication that may lead to interrupt or modify therapy.

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References

Jefferson J, Rich P. Melanonychia. Dermatol Res Pract. 2012;2012:952186. doi: 10.1155/2012/952186.

Buontempo MG, Chaudhry ZS, Raval RS, Mourtzanakis K, Ramachandran V, Shapiro J, Lo Sicco K. Hydroxyurea-induced melanonychia. JAAD Case Rep. 2023;42:91-94. doi: 10.1016/j. jdcr.2023.09.027.

Koley S, Choudhary S, Salodkar A. Melanonychia and skin hyperpigmentation with hydroxyurea therapy. Indian J Pharmacol. 2010;42(1):60-1. doi: 10.4103/0253-7613.62394.

França ER, Teixeira MA, Matias K de F, Antunes DE, Braz Rde A, Silva CE. Cutaneous effects after prolongaded use of hydroxyurea in Polycythemia Vera. An Bras Dermatol. 2011;86(4):751-4. English, Portuguese. doi: 10.1590/s0365-05962011000400019.

Karanth SS, Gupta A, Prabhu M. Melanonychia and mucocutaneous hyperpigmentation from hydroxyurea use for the treatment of essential thrombocytosis. Singapore Med J. 2014;55(1):e7-8. doi: 10.11622/smedj.2013187.

Pektas SD, Pektas G, Tetik Aydogdu C. Melanonychia Caused by Hydroxyurea in Hematologic Patients: Report of 4 Cases. Clin Dermatol J. 2018;3(1):000142. doi: 10.23880/cdoaj-16000142.

Chadha SA, Goyal PK, Lyon M. Twenty-Nail Transverse Melanonychia. JCO Oncol Pract. 2021;17(4):204-205. doi: 10.1200/OP.20.00488.

Osemwota O, Uhlemann J, Rubin A. Twenty-Nail Transverse Melanonychia Induced by Hydroxyurea: Case Report and Review of the Literature. J Drugs Dermatol. 2017;16(8):814-815.

Published
2024-06-30
How to Cite
1.
Pamo-Reyna OG. Melanonychia due to hydroxyurea. Acta Med Peru [Internet]. 2024Jun.30 [cited 2024Oct.4];41(2):144-6. Available from: http://www.amp.cmp.org.pe/index.php/AMP/article/view/2861
Section
CASE REPORTS