FOXP3 expression in T-cell lymphoma: a 47-case study in Edgardo Rebagliati-Martins Hospital; EsSalud, Lima, Peru

  • Brady Beltrán Gárate Hospital Edgardo Rebagliati Martins
  • Pilar Quiñones Ávila Hospital Edgardo Rebagliati Martins
  • Domingo Morales Luna Hospital Edgardo Rebagliati Martins
  • Esther Cotrina Montenegro Hospital Edgardo Rebagliati Martins
Keywords: Foxp3, T-cell lymphoma, ATLL

Abstract

Introduction: Foxp3 is a key regulatory gene required for CD25+ and CD4+ regulatory T-cells development and function (Treg), a cell subpopulation specialized in maintaining a balance between immunity and tolerance.
Objective: To determine the specificity and prognostic value of Foxp3 expression in T-cell lymphoma.
Material and Methods: A retrospective study carried out in 47 patients with T-cell lymphoma in Edgardo Rebagliati-Martins Hospital, EsSalud (Peruvian Social Security), from 1997 to 2004.
Results: The expression of Foxp3 in tumoral cells was detected in 8/33 (24%) ATLL (adult t-cell leukemia/lymphoma) cases and in 2/8 (29%) LTPNE cases. There was no statistically significant difference in overall survival between ATLL Foxp3 (+) and ATLL Foxp3 (-). Foxp3 is expressed in different T-cell lymphoma types, and it is not a specific marker for the dientification of ATLL cases.
Conclusion: Foxp3 expression can be seen both in ATLL as in LTPNE.

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Published
2009-06-30
How to Cite
1.
Beltrán Gárate B, Quiñones Ávila P, Morales Luna D, Cotrina Montenegro E. FOXP3 expression in T-cell lymphoma: a 47-case study in Edgardo Rebagliati-Martins Hospital; EsSalud, Lima, Peru. Acta Med Peru [Internet]. 2009Jun.30 [cited 2024Apr.25];26(2):74 -77. Available from: http://www.amp.cmp.org.pe/index.php/AMP/article/view/1497
Issue
Vol 26 No 2 (2009)
Section
ORIGINAL ARTICLES
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